Research Associate in Single Cell Analysis and Mitochondrial Ageing
Imperial College London Department of Mathematics
United Kingdom

Job summary

Applications are invited for two Research Associates in Single Cell Analysis and Mitochondrial Ageing to work in the group of Professor Nick Jones. Funding is available for each 36-month post to be extended by a further 24 months and this extension is anticipated. The appointees will work on a Wellcome funded project, alongside two experimental post-docs (also over 5 years), in the labs of Professors Patrick Chinnery and Maria Spillantini in...

Job listing information

  • Reference NAT01134
  • Date posted 8 April 2022
  • Closing date 7 June 2022

Key information about the role

  • Location South Kensington Campus (map)
  • Position type Full time, fixed term
  • Salary £41,593 – £45,234 plus benefits
  • Department Department of Mathematics
  • Category Researcher / Non Clinical Researcher

Job description

Job summary

Applications are invited for two Research Associates in Single Cell Analysis and Mitochondrial Ageing to work in the group of Professor Nick Jones. Funding is available for each 36-month post to be extended by a further 24 months and this extension is anticipated.

The appointees will work on a Wellcome funded project, alongside two experimental post-docs (also over 5 years), in the labs of Professors Patrick Chinnery and Maria Spillantini in the Cambridge Mitochondrial Biology Unit and Cambridge Clinical Neuroscience. The project will investigate, through single cell multiomics, the interplay of mitochondrial content and gene-expression with both ageing and Parkinson’s disease in the brain in both mouse models and human.

You will work directly with Nick Jones: experience in Bayesian inference is required; familiarity with single cell analysis is highly desirable; familiarity with topics in statistical genetics, variant calling and sequencing is desirable. The Imperial team will be linked to both the Centre for the Mathematics of Precision Healthcare and Imperial’s Machine Learning initiative I-X (which Professor Jones co-directs). We welcome candidates from all backgrounds and value a supportive environment prioritizing purposeful happiness.

Links for context:

http://systems-signals.blogspot.com/

https://www.imperial.ac.uk/people/nick.jones/publications.html

http://www.mrc-mbu.cam.ac.uk/people/patrick-chinnery

https://spillantinilab.medschl.cam.ac.uk/

http://www.imperial.ac.uk/mathematics-precision-healthcare/

https://ix.imperial.ac.uk/

The appointment will have strong links between Imperial College London and University of Cambridge with travel between the two sites throughout the appointment.

Duties and responsibilities

    • Inference challenges with single cell transcriptomics, scATAC-seq, variant calling, joint single cell ATAC and RNA data.
    • Designing new experiments alongside the two experimental post-docs.
    • Exploring new approaches using causal inference.
    • Processing pre-existing datasets which are both public and in house.
    • Exploring combinations of lineage inference and gene-expression clustering.
    • Exploration of appropriate models from statistical genetics.

Essential requirements

The essential requirements for this post are as follows:

  • Hold a PhD (or equivalent research, industrial or commercial experience) in Statistics, Mathematics, Physics, Computer Science or a closely related discipline
  • Strong interest in the project
  • Strong track record of high-quality independent research, commensurate with career stage

Experience in:

  • Bayesian Inference

Experience and knowledge in one or more of the following techniques:

  • Computational Statistics
  • Single Cell transcriptomics
  • Single Cell variant calling
  • Statistical Genetics

Further information

The position is full time and fixed term for 36 months with the possibility of a 24 month extension. You will be based at South Kensington Campus and travel to University of Cambridge will be required.

The expected start date is 1 October 2022 or soon thereafter.

*Candidates who have not yet been officially awarded their PhD will be appointed as Research Assistant within £36,694 - £39,888 salary range per annum.

In addition to completing the online application, candidates should attach:

  • A full CV,
  • A 1-page research statement describing why the candidate’s expertise is relevant to this position and future research plans; and
  • The details of three referees.

For any specific queries regarding the post please contact Prof Nick Jones, (nick.jones@imperial.ac.uk). 

The College is a proud signatory to the San-Francisco Declaration on Research Assessment (DORA), which means that in hiring and promotion decisions, we evaluate applicants on the quality of their work, not the journal impact factor where it is published. For more information, see https://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-evaluation/

The College believes that the use of animals in research is vital to improve human and animal health and welfare. Animals may only be used in research programmes which are ultimately aimed towards finding new treatments and making scientific and medical advances, and where there are no satisfactory or reasonably practical alternatives to their use. Imperial is committed to ensuring that, in cases where this research is deemed essential, all animals in the College’s care are treated with full respect, and that all staff involved with this work show due consideration at every level. Find out more about animal research at Imperial.

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