Research Associate/Fellow (2 posts, fixed-term) in Mathematical Sciences University of Nottingham, Department of Mathematical Sciences United Kingdom

Research Associate/Fellow (2 posts, fixed-term)


Reference
SCI470518


Closing Date
Wednesday, 16th January 2019


Job Type
Research


Department
Mathematical Sciences


Salary
£27025 to £38460 per annum (pro-rata if applicable) depending on skills and experience (minimum £30,395 with relevant PhD). Salary progression beyond this scale is subject to performance


We are looking for 2 researchers whose expertise lies in modelling and simulation applied to biology OR fitting mathematical models to real-world data, to work with Dr Gary Mirams on a £2M Wellcome-funded project entitled “Developing cardiac electrophysiology models for drug safety studies”. The central aim of the project is to develop and improve cardiac electrophysiology models to the stage that they can be used for prediction of drug action and subsequent clinical pro-arrhythmic risk.

 

We are looking for expertise in EITHER mathematical modelling of the dynamics of a biological system, involving numerical simulations e.g. ODE, PDE or agent-based modelling OR extensive statistics/data science experience – for instance, fitting statistical/mechanistic models to data, performing uncertainty quantification/inference with methods such as MCMC.

 

The particular applications for these roles are respectively: 1) to develop methods and experiments to tailor mathematical models of cellular electrophysiology (action potential models) to particular batches of stem-cell derived cardiomyocytes and other cell types, particularly considering use of data from the dynamic clamp technique [5]; and 2) to develop a statistical/uncertainty quantification framework in which to consider our models’ inputs and parameters (and also model structures/equations); to compare model predictions with real experiments.

 

We believe that talented and inclusive teams deliver the highest quality research and are seeking applications from high quality candidates who enhance the diversity of our existing team. The School is committed to creating opportunities for people traditionally under-represented in Mathematical Sciences.

 

We are looking for confident, organised researchers who can evidence:

  • A PhD, or equivalent in mathematics/statistics/physics or closely-related discipline.
  • Expert knowledge of either: Modelling a biological system using numerical simulations OR Optimisation / inference of model parameters from experimental data and Uncertainty Quantification
  • Background knowledge in more than one of the following areas:

 

  1. Electrophysiology
  2. Model selection
  3. Experiment design
  4. Scientific computing in one of Matlab / C++ / Python / R
  5. Software engineering – testing, version control

 

  • Excellent computer programming skills
  • Excellent communication and organisational skills
  • The ability to work both independently and as part of a multidisciplinary and multicultural team 

 

These 2 full-time positions are available from 1 February2019 or as soon as possible thereafter and will be offered on a fixed-term contract for a period of 36 months. Job share arrangements may be considered.

 

For information about the School of Mathematical Sciences and active research groups in the Centre for Mathematical Medicine & Biology see: http://www.nottingham.ac.uk/mathematics/index.aspx.

 

Informal enquiries may be addressed to Gary Mirams email: gary.mirams@nottingham.ac.uk. Please note that applications sent directly to this email address will not be accepted.

 

The University of Nottingham is an equal opportunities employer and welcomes applications from all sections of the community.


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